Enzyme Cleaners vs. Regular Cleaners: What Dog Parents Need to Know

Walk down the pet aisle at any store and you'll see dozens of products promising to eliminate pet odors. But here's what they don't tell you: most of them don't actually work on urine.
Let's break down why—and how to choose a cleaner that actually does the job.
The Difference: Regular vs. Enzyme Cleaners
How Regular Cleaners Work (And Why They Fail)
Traditional cleaners use one of two approaches:
- Surfactants lift dirt and grime (but can't break down uric acid)
🔑 Key Takeaways
- •Regular cleaners mask odor—enzymes eliminate it
- •Enzymes break down uric acid crystals that cause lingering smell
- •Let enzyme cleaners air dry for best results
- •Store enzyme products at room temperature
- Fragrances mask odors (temporarily)
- Some use oxidizers that can bleach fabrics
- None of these eliminate the source of urine odor
How Enzyme Cleaners Work
Enzyme cleaners take a completely different approach. They contain beneficial bacteria that produce enzymes specifically designed to break down organic matter:
- Protease enzymes break down proteins
- Amylase enzymes break down starches
- Lipase enzymes break down fats
- Uricase enzymes specifically target uric acid
The bacteria literally consume the urine and convert it into carbon dioxide and water. When there's nothing left to eat, they die off naturally.
What to Look For When Buying
1. Bio-Enzymatic or Enzymatic Formula
The label should specifically say 'enzymatic' or 'bio-enzymatic.' Vague terms like 'natural' or 'organic' don't mean the product contains the right enzymes.
2. No Artificial Fragrances

🏆⚗️ Pro-Grade Enzyme Cleaner
Biokleen Bac-Out is plant-based and tough on pet messes—works on laundry too.
Fragrance doesn't help—it just covers up what's still there. Plus, some dogs are attracted to new scents and may mark over them. Look for 'unscented' or 'fragrance-free.'
3. Safe for Your Specific Surfaces
Not all enzyme cleaners are safe for all surfaces. Check that your cleaner is approved for:
- Carpets and rugs
- Hardwood (if applicable)
- Upholstery and furniture
- Pet bedding and fabrics
4. Pet and Child Safe
Look for products that are safe once dry. Avoid cleaners with:
- Chlorine or bleach
- Ammonia (smells like urine to dogs)
- Phenols (toxic to pets)
- Isopropyl alcohol in high concentrations
5. Concentrated vs. Ready-to-Use
Concentrated formulas offer better value per use, but ready-to-use is more convenient. Consider how often you'll need it.
Price Comparison: What You're Really Paying For
Cheap cleaners often seem like a good deal until you realize you need to use 3x as much—or they simply don't work.
Here's a rough breakdown of what quality enzyme cleaners typically cost:
- Budget: $8-12 (may need multiple applications)
- Mid-range: $15-25 (our recommended sweet spot)
- Premium: $30+ (professional-grade, concentrated)
Our Recommended Enzyme Cleaners
Best Overall: Naturally It's Clean
Plant-based enzyme formula, no artificial fragrances, works on carpet and upholstery. Great for everyday accidents.
→ See Naturally It's Clean on Amazon
Best Value: Sunny & Honey Enzymatic
Concentrated formula means better value per use. Works on both fresh and old stains.
Best for Laundry: OdorKlenz Booster
Earth mineral technology for fabrics. Add to any wash cycle to eliminate odors from pet bedding.
Common Myths Debunked
Myth: Vinegar kills pet odor
Vinegar can help with some odors, but it can't break down uric acid crystals. It also smells enough like urine that some dogs will mark over it.
Myth: Baking soda is enough
Baking soda can absorb surface odors, but it can't penetrate carpet fibers or padding where urine soaks in.
Myth: Steam cleaning fixes everything
Heat can actually set protein-based stains and spread the affected area. Always use enzyme cleaner first.
The Bottom Line
If you're dealing with dog urine, enzyme cleaners aren't optional—they're necessary. Regular cleaners simply can't eliminate the source of the odor.
Our top pick is Naturally It's Clean—it works, it's plant-based, and it won't break the bank.

🏆👉 Don't Miss: Naturally It's Clean Carpet Upholstery Cleaner
Plant-based enzyme cleaner for carpets, upholstery, and drapes—safe for use around pets.





