Naturally It's Clean vs. Standard Enzyme Cleaners: Which Works Better?

When we first heard about Naturally It's Clean, we were skeptical. A plant-based enzyme cleaner that works as well as the heavy-duty formulas? We had to test it ourselves.
Here's our honest comparison after 8 weeks of testing on real dog accidents.
The Contenders
Naturally It's Clean
- 100% plant-based enzyme formula
- No dyes, artificial fragrances, or harsh chemicals
- Works on carpet, upholstery, and drapes
- Price: ~$15-18 for 24oz
Standard Enzyme Cleaners
We tested against three popular enzyme cleaners: Nature's Miracle, Rocco & Roxie, and a generic store brand.
Test Methodology
We set up controlled tests using dog urine samples (yes, really) on identical carpet squares:
- Fresh stains (cleaned within 10 minutes)
- Day-old stains
- Week-old set-in stains
- Double-layer stains (accidents on top of old accidents)
Each cleaner was applied according to package directions, allowed to work for the same amount of time, and evaluated after 24 hours using both smell tests and UV light inspection.
Results: Head-to-Head
Fresh Stains
Winner: Tie
All enzyme cleaners handled fresh stains well when used correctly. The key is catching accidents early and saturating the area.
Day-Old Stains
Winner: Naturally It's Clean (slight edge)
We noticed slightly better results with Naturally It's Clean on 24-hour-old stains. The plant-based formula seemed to penetrate fibers effectively, and there was less residual odor in humidity tests.
Week-Old Set-In Stains
Winner: Tie (all required multiple applications)
No enzyme cleaner completely eliminated week-old stains in one application. All needed 2-3 treatments. Naturally It's Clean and Rocco & Roxie performed similarly; the generic brand lagged behind.
Odor Elimination
Winner: Naturally It's Clean
This is where the unscented formula really shines. Without artificial fragrances, it was easier to verify that the actual odor was eliminated—not just covered up.
Pros and Cons
Naturally It's Clean: Pros

🏆Also Worth Checking: Stain Remover Enzymatic Odor Eliminator
Powerful enzymatic formula that eliminates pet stains and odors from carpets, furniture, and more.
- No artificial fragrances (easier to verify it's working)
- Plant-based (peace of mind for eco-conscious pet parents)
- Effective on upholstery and drapes (not just carpet)
- No dyes that could stain light fabrics
Naturally It's Clean: Cons
- Slightly higher price point than some competitors
- Less widely available in stores (mostly online)
- Requires same patience as any enzyme cleaner (no instant results)
Standard Enzyme Cleaners: Pros
- Widely available in stores
- Often lower price point
- Some come with attachments for upholstery
Standard Enzyme Cleaners: Cons
- Fragrances can mask rather than eliminate odors
- Some contain dyes that can stain
- Quality varies significantly between brands
Which Should You Choose?
Choose Naturally It's Clean if:
- You want a fragrance-free option
- You're concerned about chemicals around pets/kids
- You need to clean upholstery or drapes
- You want to be sure the odor is actually gone
→ Get Naturally It's Clean on Amazon
Choose Standard Enzyme Cleaners if:
- You need something available at local stores today
- Budget is your primary concern
- You prefer a scented product
Our Verdict
For pet parents who want the peace of mind that comes with a plant-based, fragrance-free formula, Naturally It's Clean is our top pick. It performs as well as—and in some cases better than—conventional enzyme cleaners.
The slightly higher price is worth it when you consider that you're not just masking odors with fragrance. You know it's actually working.
After 8 weeks of testing, Naturally It's Clean earned a permanent spot in our cleaning closet—and our recommendation.
→ Try Naturally It's Clean and see for yourself.

Naturally It's Clean Carpet Upholstery Cleaner
Check price on Amazon
🏆✅ Our Recommendation: Naturally It's Clean Carpet Upholstery Cleaner
Plant-based enzyme cleaner for carpets, upholstery, and drapes—safe for use around pets.




