The catch: Old stain? Soak it at bedtime and let it work overnight.
What's in it: chlorine-free and color-safe, so colored carpet is on the table. Source: Listing
The maker states: Enzyme formulaThe maker states: it uses enzymes, which break down the pee or vomit itself, so the smell goes with it.
The maker states: Made in USAThe maker states: it is made in the USA, with no qualifier. Under FTC rules, that claim has to mean all or virtually all of it is made here.
Short answer: Naturally It's Clean wins on fresh pee and for homes that want no artificial perfume (the maker says it has no artificial fragrances). A standard enzyme cleaner like Rocco & Roxie wins on set-in stains. Any good enzyme cleaner needs a full soak and a second round on a big old stain.
Here's how they stack up on the messes that matter.
In the ring: plant-based vs standard
Naturally It's Clean
Plant-based enzyme formula
No dyes, artificial fragrances, or harsh chemicals
Works on carpet, upholstery, and drapes
Standard Enzyme Cleaners
We compared it with three popular options: Nature's Miracle, Rocco & Roxie, and a generic store-brand enzyme spray.
We sorted them by the four stains owners deal with most:
Fresh stains (cleaned within 10 minutes)
Day-old stains
Week-old set-in stains
Double-layer stains (accidents on top of old accidents)
For each one, two questions: is the smell gone or just masked, and does the cleaner's own scent linger? All four use the same method: soak the spot, give the enzymes time, and let it air dry.
What the labels and owner reports show
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Fresh Stains
Edge: Even
Any enzyme cleaner handles a fresh spot when it reaches as deep as the pee did. Blot first, then soak. Most failed fresh-stain reviews describe a light mist that never reached the pad.
Day-Old Stains
Edge: Naturally It's Clean (slight)
The formulas work the same way, so the edge here is about checking your work. With no perfume on top, a day-old spot either smells clean after it dries or it does not, and you know to treat it again.
Week-Old Set-In Stains
Edge: Even (plan on more than one round)
No enzyme cleaner promises a one-pass fix on a week-old stain. What works: soak to the pad, cover the spot so it stays wet, and repeat after it dries. Generic sprays draw more "smell came back" complaints, often from lighter application.
No enzyme cleaner promises a one-pass fix on a week-old stain.
Odor Elimination
Edge: Naturally It's Clean
This is where skipping artificial perfume earns its place. Nature's Miracle's current formula draws steady owner complaints that its perfume lingers for days, which makes it hard to tell if the urine smell is gone. Rocco & Roxie's scent is lighter but still noted. Naturally It's Clean has no heavy perfume on top, so a pee smell it missed is easier to notice.
Pros and Cons
Naturally It's Clean: pros
No artificial fragrances (easier to verify it's working)
Enzymes the maker calls plant-based
Effective on upholstery and drapes (not just carpet)
No dyes to stain light fabrics
Naturally It's Clean: cons
Less widely available in stores (mostly online)
Requires same patience as any enzyme cleaner (no instant results)
Standard enzyme cleaners: pros
Widely available in stores
Some come with attachments for upholstery
Standard enzyme cleaners: cons
Fragrances can mask rather than eliminate odors
Some contain dyes that can stain
Quality varies significantly between brands
Which should you choose?
Choose Naturally It's Clean if:
You want a cleaner without artificial fragrance
You're concerned about chemicals around pets/kids
You need to clean upholstery or drapes
You want to be sure the odor is actually gone
→ Get Naturally It's Clean on Amazon
Choose standard enzyme cleaners if:
You need something available at local stores today
You want a familiar enzyme formula off the shelf
You prefer a scented product
Our Verdict
For homes that want no artificial fragrance, Naturally It's Clean is our top pick, and the maker calls its enzymes plant-based. On paper it does the same job as conventional enzyme cleaners, and the lack of perfume makes it easier to confirm the smell is gone.
The catch: it is mostly sold online, and it asks for the same patience as any enzyme cleaner. Skip it if you want a scented product, or if you need a bottle from a local store today.
Naturally It's Clean earns our recommendation.
→ Try Naturally It's Clean for fabric and carpet spots.
