Naturally It's Clean vs Rocco & Roxie: Fresh Pee or Old Stain?

Stop guessing.

By the Clean Fluff Club team. Published October 13, 2026. How we picked.

  1. Our pick

    Naturally It's Clean Carpet Upholstery Cleaner

    Best for: Fresh pee on carpet and couches

    The catch: Old stains need a few rounds.

    Skip it if: The stain is old and set in, and needs a longer soak.

  2. Rocco & Roxie Professional Strength Enzyme Cleaner

    Best for: Old, dried cat or dog pee on carpet

    The catch: Old stain? Soak it at bedtime and let it work overnight.

    Check price at Amazon
In this guide

Fresh puddle: Naturally It's Clean. Old stain: Rocco & Roxie.

You found it. How old is it? Fresh: blot, spray, let it sit, blot again with Naturally It's Clean. Dried weeks ago: Rocco & Roxie, the overnight soak.

Which one to get: pick by the age of the stain

  • Get Naturally It's Clean if the pee is fresh and on carpet, or you want a cleaner that advertises plant-based enzymes and no dyes or artificial fragrances. Blot, spray, let it sit, blot again. The catch: it is built for fresh carpet spots, so for a set-in stain switch to Rocco & Roxie.
  • Get Rocco & Roxie if the pee is dried, keeps coming back to the same spot, or sits on tile, wood or concrete. Soak it, leave it overnight, let it air dry. The catch: you need patience, and it is made for pee, poop and vomit. Ink or dye? Reach for a spot remover.

Find your stain, find your bottle

  • Stain age: fresh and damp points to Naturally It's Clean. Dried or repeat spots point to Rocco & Roxie.
  • Surface: Naturally It's Clean is made for carpets. Rocco & Roxie is made for carpet plus tile, wood and concrete.
  • Wait time: Rocco & Roxie wants longer on a fresh spot: its product page says let it stand 30 to 60 minutes, then blot. On old pee, overnight. Naturally It's Clean is the spray-and-blot bottle for a fresh puddle.
  • Scent: Naturally It's Clean says no artificial fragrances. Rocco & Roxie lists fragrance among its ingredients on its product page.
  • What else it covers: Naturally It's Clean breaks down food, wine, coffee and pet stains. Rocco & Roxie is made for pee, poop and vomit.
  • Steam cleaner: Rocco & Roxie says not to run it through one, because the high heat can deactivate its biological ingredients.

Fresh pee on carpet: Naturally It's Clean wins

Fresh and damp is the spray-and-blot job. Blot, spray, let it sit, blot again. Naturally It's Clean advertises no dyes or artificial fragrances, and it is made for carpets.

Winner: Naturally It's Clean, for a fresh spot on carpet.

Old, dried or repeat spots: Rocco & Roxie wins

The directions are about time, not scrubbing. Pour it on until it reaches as deep as the pee did, leave it overnight, then let it air dry. On carpet, soak past the visible edge, because pee spreads wider underneath than it looks on top.

Rocco & Roxie says it is chlorine-free and color-safe. Spot-test a hidden corner of the rug first anyway.

Rocco & Roxie Professional Strength Enzyme Cleaner

Also great

Rocco & Roxie Professional Strength

Best for: Old, dried cat or dog pee on carpet

Winner: Rocco & Roxie, because the overnight soak is the whole design.

Tile, wood and concrete: Rocco & Roxie wins

Rocco & Roxie is made for tile, wood and concrete. Pour it on and leave it. On wood, let the first round dry fully before you add more, so the boards dry between rounds.

Rocco & Roxie Professional Strength Enzyme Cleaner

Also great

Rocco & Roxie Professional Strength

Best for: Old, dried cat or dog pee on carpet

Naturally It's Clean's page covers carpets, so keep it for the rug.

Winner: Rocco & Roxie.

Fragrance: Naturally It's Clean wins

Want to skip artificial scent? Naturally It's Clean advertises no dyes or artificial fragrances. Rocco & Roxie lists fragrance among its ingredients.

Winner: Naturally It's Clean, on scent.

Neither if

  • The smell is still there after two full rounds with dry time between them. The pee has probably reached the pad or the subfloor. Read the deep fix for pad and subfloor.
  • The stain is ink or dye. Both bottles are made for organic messes, so reach for a spot remover.

Want the full list?

Every bottle, matched to its mess, is in our enzyme cleaners for dog urine roundup. Not sure how long to wait between rounds? See how long enzyme cleaners take to work. Weighing a third bottle? Read Nature's Miracle vs Rocco & Roxie.

Your next move

Questions people ask

Can I use both on the same spot?

Pick one per round. Start with Naturally It's Clean on a fresh spot. If the smell is still there after two full rounds with dry time between them, switch to Rocco & Roxie: soak it, leave it overnight, let it air dry.

Does Rocco & Roxie work on carpet?

Yes, it is made for carpet and for tile, wood and concrete. Soak the spot as deep as the pee went, leave it overnight, and let it air dry.

Which one for an old stain?

Rocco & Roxie. Its directions are built around long soaks, with overnight for older spots.

Still deciding? Get this one.

Naturally It's Clean Carpet Upholstery Cleaner
Naturally It's Clean Carpet Upholstery Cleaner

Best for: Fresh pee on carpet and couches

Read the Naturally It's Clean Carpet Upholstery review

Still fighting this mess?

Not sold on this one? Line it up against every odor and stain cleanup pick.

Each pick is matched to one job, with its catch up front and who should skip it.